Polymères biodégradables anioniques dérivés de l'acide aminé l

Polymères biodégradables anioniques dérivés de l'acide aminé l–tyrosine

N° de brevet:	EP1908490 (A1)
Date de publication:	2008-04-09
Inventeur(s):	KOHN JOACHIM B [US];BOLIKAL DURGADAS [US];BRODE GEORGE L [US];ERTEL SYLVIE I [FR];GUAN SHUIYUN [US];KEMNITZER JOHN E [US];
Demandeur(s):	UNIV RUTGERS [US];
Classification:	A61M31/00;C07K14/00;C08G64/12;C08G64/16;C08G63/685;C08G69/10;A61L17/10;A61L27/18;A61L31/06;A61L31/14;C08G63/672;C08G64/04;C08G64/06;C08G64/18;C08G69/44;C08L101/16;
N° de demande:	EP20080150717 19981107
Numéro(s) de priorité:	EP20040016935 19981107;EP19980957728 19981107;US19970064656P 19971107;US19980056050 19980407

A biodegradable, biocompatible polymer, comprising a combination of monomeric repeating units having structures I and IV wherein R9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendant benzyl carboxylic acid ester group and; R12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from the group consisting of straight and branched alkyl and alkylaryl esters containing up to 18 carbon atoms and ester derivatives of biologically and pharmaceutically active compounds covalently bonded to said polymer, provided that said ester group is not a benzyl group or a group that is removed by hydrogenolysis.