Composants de type aryloxy et arylthioxyacetophenone pour le traitement du cancer

N° de brevet: EP1894917 (A1)
Date de publication: 2008-03-05
Inventeur(s): EBERLE MARTIN [CH];BACHMANN FELIX [CH];STREBEL ALESSANDRO [CH];ROY SUBHO [IN];SAHA GOUTAM [IN];SADHUKHAN SUBIR KUMAR [IN];SAXENA ROHIT [IN];SRIVASTAVA SUDHIR [IN];
Demandeur(s): BASILEA PHARMACEUTICA AG [CH];
Classification: C07D213/85;A61K31/44;A61P35/00;A61K31/34;A61K31/435;C07D307/79;C07D307/82;C07D493/04;
N° de demande: EP20070118973 20041221 
Numéro(s) de priorité: EP20040804957 20041221;EP20030405911 20031222;EP20030405912 20031222;EP20040405517 20040819;EP20070118973 20041221 
The invention relates to compounds of formula (II) wherein ring A is a phenyl, pyridine, pyrimidine or pyrazine ring, W and X are carbon or nitrogen, Y is oxygen or sulfur, R 0 is different from hydrogen, R x is -(C="O")R 1 or cyano; R 1 is hydrogen, optionally substituted hydroxy or optionally substituted amino, and the other substituents are as described in the specification. The invention further relates to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (II), to the use of a compounds of formula (II) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (II) or pharmaceutical compositions containing same.

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