This invention relates to a production process of tobacco sheet by papermaking. The technical arrangement of this invention are: (a). to immerge and to extract tobacco stem and leaf scrap respectively by water-soluble solvents to respectively obtain solid tobacco stem and solid leaf scrap, and tobacco stem extract and leaf scrap extract via solid/liquid separation; (b). to defibrillate solid tobacco stem and solid leaf scrap respectively, to mix the obtained tobacco stem fiber and leaf scrap fiber and combined with dust to prepare fiber base; (c). to wholly or partly abnegate the tobacco stem extract obtained by Step (a), and to evaporated and to concentrate other extracts that then are sprayed or immerged to coat the formed fiber base that is then dried, threshed and shaped. The tobacco sheet production process offered by this invention has improved the tobacco sheet's filling capacity and its sensory quality.