DERIVE DE BENZAMIDE OU SEL DE CE DERNIER

N° de brevet: EP1632477 (A1)
Date de publication: 2006-03-08
Inventeur(s): KURAMOCHI TAKAHIRO [JP];ASAI NORIO [JP];IKEGAI KAZUHIRO [JP];AKAMATSU SEIJIRO [JP];HARADA HIRONORI [JP];ISHIKAWA NORIKO [JP];SHIRAKAMI SHOHEI [JP];MIYAMOTO SATOSHI [JP];WATANABE TOSHIHIRO [JP];KISO TETSUO [JP];
Demandeur(s): ASTELLAS PHARMA INC [JP];
Classification: A61K31/167;A61K31/428;A61K31/4453;A61K31/454;A61K31/4709;A61K31/4725;A61K31/496;A61K31/5377;A61K31/538;A61K31/55;A61P1/04;A61P11/00;A61P11/06;A61P13/10;A61P17/04;A61P25/06;A61P29/00;C07C237/40;C07D209/08;C07D209/36;C07D213/75;C07D215/38;C07D217/04;C07D223/16;C07D231/56;C07D235/06;C07D241/42;C07D249/18;C07D263/58;C07D265/36;C07D277/62;C07D277/82;C07D279/16;C07D295/155;C07D317/64;C07D333/54;C07D401/12;C07D409/12;C07D413/12;C07D417/12;C07D417/14;C07D471/04;
N° de demande: EP20040736576 20040610 
Numéro(s) de priorité: WO2004JP08479 20040610;JP20030167865 20030612;JP20030405086 20031203 
There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine, cluster headache, bladder diseases including overactive bladder, and the like. A benzamide derivative or a salt thereof wherein a benzene ring is attached to a D ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring) through an amide bond, the benzene ring is directly bonded to an E ring (a monocyclic or bicyclic hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (an amino moiety, a monocyclic or bicyclic heterocycle) through L (a lower alkylene).

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